Saudi Journal of Pathology and Microbiology (SJPM)
Volume-5 | Issue-08 | 385-387
Case Report
Exaggerated Placental Site Reaction Following a Term Pregnancy: A Case Report
Rajeev Sen, Bharti Sharma, Ritesh Kumar Sheorain, Nikita Prasad, Pushpa Bisht, Swarnim Dalakoti
Published : Aug. 20, 2020
Abstract
Exaggerated placental site (EPS) reaction is an exuberant physiologic process wherein intermediate trophoblasts infiltrate the underlying endometrium and myometrium at the implantation site. Its diagnosis is established only histopathologically which reveals proliferation of intermediate trophoblasts at the implantation site with absence of mitotic activity. Distinguishing EPS reaction from other trophoblastic tumors is crucial due to difference in management and prognostic outcome. We reported a case of 35 years old multigravida female who presented to the hospital at gestational age of 39+6 weeks with complaints of persistent post-delivery bleeding. We received a hysterectomy specimen in our department. Grossly the specimen measured 14cm x 14cm x 8 cm and endometrial cavity was filled with hemorrhagic soft tissue. On microscopy, microsections revealed gravid uterus with numerous intermediate trophoblasts extending into but confined to the myometrium; a diagnosis of exaggerated placental site rophoblastic reaction was made. EPS can develop anytime from early to term pregnancy. Clinical features are non-specific such as abdominal pain, high grade fever, continuous bleeding per vaginum. Only 12 cases have been reported in English literature based on PubMed from 1990 through 2020. EPS is rare and diagnosis is chiefly histopathological. It should be considered albeit rare as a differential diagnosis of heavy bleeding after a delivery or abortion. It is necessary to differentiate this entity from other neoplastic pathologies of trophoblast, since it does not require any surgical treatment or follow up.