Ketamine, an N-methyl –D-aspartate (NMDA) antagonist, has been abused as a recreational drug due to its euphoric, dissociative, and hallucinogenic characteristics. Series of studies have been carried out on the effect of ketamine on cognition and memory. However, there is dearth literature on the activities of ketamine as a recreational drug of abuse; its effect on motor response in association with cognitive behaviours in Wistar rat models. Hence, this study is necessary to investigate the effects of chronic administration of sub-anesthetic doses of ketamine on perceptual, cognitive, and motor responses in Wistar rats. 25 Wistar rats (160-180 kg) were randomly selected into five groups and treated for three weeks thus: Group 1 (control), Group 2 (0.2 mL Ketamin-i.p), Group 3 (0.4 mL Ketamin-i.p), Group 4 (0.6 mL Ketamin-i.p) Group 5 (0.5 mL Cerebrex-orally). Neurobehavioral (Barnes, rotarod, and handgrip) activities exhibited by the various groups were recorded and analyzed using ANOVA. In the Barnes maze test, there was a significant increase (p<0.05) in escape time from weeks 1, 2 and 3 in groups 2, 3 and 4 when compared to control. In week 2 and 3 of the handgrip test, animals in group 4 had a significant improvement (p<0.05) in grip strength when compared to control. In weeks 1 and 2 of the rotarod test, groups 2 and 4 animals respectively, showed a significant increase (p<0.05) in balance compared to control. Sub-anesthetic doses of ketamine inhibited cognitive function but not motor responses in Wistar rats.