General and hand hygienic practices are cost-effective methods to prevent the transmission of nosocomial infections. Hand hygiene practices are faulty in most healthcare settings. This study is designed to assess the general and hand hygiene practices among medical and nursing students of the University of Hail in the Kingdom of Saudi Arabia. This is a cross-sectional study conducted among medical and nursing students. A detailed questionnaire was prepared and piloted before the final interview. The participation of students was voluntary and the questionnaires were kept anonymous. The majority of the medical and nursing students, who participated in this study, were males (88%), with 94% in the college of medicine and 82% in the college of nursing. The majority of both medical and nursing students had good hygienic and good hand washing practices. Hand washing practices were almost similar (p>0.05) in both male and female students. This study showed a higher percentage of general and handwashing hygienic practices among medical and nursing students. However, multifaceted and dedicated efforts must be undertaken to rectify this practice from early on.