Background: Stromal tumors arising in GastroIntestinal tract were generally regarded as smooth muscle neoplasms such as leiomyoma, leiomyosarcoma, leiomyoblastoma and bizarre leiomyomas but relatively few of these neoplasms had convincing ultrastructural evidence of smooth muscle differentiation. Aims & objectives: The main aim of the study is to review cases of Gastrointestinal Stromal Tumors and to categorize these neoplasms based on the “risk of metastasis”. Materials & methods: The study was done for three years and we received 30 specimens consisted of resections and biopsies from gastrointestinal tract in the department of pathology and diagnosed as Gastrointestinal Stromal Tumors, for which we assessed the risk of metastasis. Results: There was a preponderance of high risk Gastrointestinal Stromal Tumors with 21 cases (70%), followed by intermediate risk 5 cases (16.67%), low risk 2 cases (6.67%) and very low risk 2 cases (6.67%). Conclusion: Gastrointestinal stromal tumors are a heterogenous group of neoplasms. With the advent of targeted therapy using gleevac the responsibility of the pathologists has increased to give a specific diagnosis. It is also important to suggest the prognosis based on the pathological findings.