Odontogenic pain is very common among pregnant women. Pregnant patients and their fetuses are more at risk when they experience pain, which frequently comes along with periapical or pulp infections. Therefore, it is crucial to offer adequate pain relief and eradication of the infection for the pregnant woman while maintaining the safety of fetus inside the womb. Antibiotics are used in endodontic treatment; thus, the choice of appropriate and safe antibiotic for pregnant patients is very important. The current study will highlight the antibiotics that can be used in the treatment of dental-related infections during pregnancy.