Crohns Disease also referred to as regional enteritis is a chronic disease with waxing and waning course. This condition is associated with profound psychological and physical effect on the affected patient. The disease has diverse clinico-pathological manifestations with significant attendant complications, morbidity and mortality. In this study attempt is made to address the many clinico-pathological presentations of the disease with focus on various aspects of differential diagnosis along with description of diagnostic approach by appropriate use of variousdiagnostic modalities. In addition recent pathogenetic mechanisms will be described which will having bearing and implications on therapeutic aspects of disease, that can influence the natural history and overall course of disease. This case is presented in view of its uncommon location and associated clinical manifestation.