Background and Objectives: Psoriasis is a chronic papulosquamous disorder with constant exacerbations and remissions. Based on the clinical overlap with other papulosquamous disorders and the role of histopathology in diagnosis, we undertook a study on psoriasis. The objective of this study was to identify combination of histopathological parameters for the diagnosis of psoriasis and establish their reliability and significance. Material and Methods: A retrospective cum prospective study over a period of 5 years was carried out. 56 clinically diagnosed cases of psoriasis were taken into consideration. Skin biopsies were taken from these cases and histopathological examination was done. These lesions were then assessed based on various histopathological parameters. Results and Discussion: Maximum number of cases were in the age group of 31–40 years, males being three times more affected than females. The most common symptom was pruritis and psoriasis vulgaris was the most common variant. Upper limbs and back were most frequently affected. Among the microscopic parameters, acanthosis and parakeratosis were observed and when present with features like hypogranulosis, elongation of rete ridges, dermal inflammation and vasodilation or perivascular lymphocytic infiltrate were likely to indicate psoriasis. Munro micro abscesses and spongiform pustules of Kogoj, diagnostic features of psoriasis were also seen in significant proportion. Conclusion: Diagnosis of psoriasis is made based on the analysis of clinical symptoms and signs with a correlation with histopathological features. The relative ambiguity associated with this disease makes such histopathologic studies all the more important.