Background: Acne is a chronic inflammatory disease known to occur in adolescent age group. There are many myths and misconceptions in adolescent as well regarding the prevention and treatment of acne. Objectives: The main goal of this study to assess awareness regarding acne vulgaris among adolescent students in Kamel Ibrahim and Abdulla Ibn Abbas secondary school in Shendi town. Method: This was descriptive study conducted among 100 students in secondary schools, data was collected by self-administered structured questionnaire using multistage stratified sample. Data was analyzed by using statistic package for social sciences (SPSS) version (20). Result: The study clarified that approximately half (49%) of study group their age between (13- 15) years, while (56%) of them had poor knowledge about definition of acne also (16%),(12%) of them had fair knowledge about type and site respectively and majority (88%) (83%) of them had poor knowledge about psychological problem and prevention of acne. Conclusion: The finding of the study pointed out that students had low level of awareness regarding acne in spite of it appear in this period.