Objectives: The systematic review objective was designed to assess the effects of local interventions used for the prevention and treatment of pain associated with orthodontic treatments. Methods: A digital literature search was carried out between 2000 and 2022 in the following databases, Scopus, Google Scholar, PubMed, and the Cochrane Library of Systematic Reviews. Results: Orthodontic patients' quality of life was significantly impacted negatively by the discomfort associated with fixed orthodontic equipment. There were poor dental hygiene, slurred speech, difficulty chewing, movable teeth, decreased taste, halitosis, and gingival bleeding which were frequently the main indicators of pain. Conclusion: Patients might, to some extent, prevent pain and suffering with the support of effective orthodontist- patient dialogue and targeted dietary guidance. However, analgesics continue to be a trusted and widely used method for subsiding painful sensations.