Leptospirosis is a contemporary zoonotic disease that spread through the direct and indirect contact with animals and its excreta. The rising nuisance of this communicable disease is increasing now days due to handling the pet animals by the family members and allow them upto beds. In most places, placing the pet on the lapses may increase the load of the infections directly from the pet to the humans. The bacterial and serological observations among the infectious individuals are rising steadily but very few eliciting clinical symptoms. Among of the exposures, the immunity scores the individuals and protect from the infection. Eventhough we have good and effective antimicrobials to kill the leptospires and control leptospiral complications, clinicians are not still aware about the pyrexia of unknown origin may be due to leptospirosis. Thus most of the positive cases may leads to chronic state of multiorgan dysfunction to multiorgan failure; in few situations, renal failure, pulmonary and cardiac issues leads to increased mortality. From this review it is requested to all the pet owners to keep your pets in separate place not in your living areas and hopefully asking the clinicians to consider leptospirosis also as one of the suspicions among PUOs.