Background: Fine Needle Aspiration Cytology (FNAC) is worldwide accepted, inexpensive, minimally invasive and very accurate method today especially in commonly encountered clinical problems like salivary gland lesions which range from non-neoplastic lesions like inflammation, cysts, and commonest benign tumours like pleomorphic adenoma to malignant lesions of variable malignant potential. FNAC is major diagnostic tool and is of great relevance in head and neck lesions, including major salivary glands as they are easily accessible target sites. The aim of this study was to evaluate spectrum of salivary gland lesions with their clinical presentations and to study the cytomorphological features of various salivary gland lesions, and to evaluate its sensitivity and specificity of FNAC in salivary gland lesions whenever histopathology was available. Material and Methods: A total of 150 cases of salivary gland lesions were analysed both retrospectively and prospectively from January 2010- December 2015 at Department of Pathology, of a tertiary care medical college Hospital. Cyto-histopathological correlation was interpreted wherever available. Results: In the 150 cases thus analysed, the male to female ratio was 1.14:1. Parotid gland was involved in 73.34 %, submandibular gland in 23.33 %, and other minor salivary glands in 3.33% of patients. There were 57.33 % cases of neoplastic lesions and 42.67% cases of non-neoplastic lesions. Chronic sialadenitis (22.67%) was the commonest non neoplastic lesion. Pleomorphic adenoma (40.67%) was the commonest benign neoplasm and Mucoepidermoid carcinoma (9.33%) was the commonest malignant neoplasm. The overall sensitivity, specificity and diagnostic accuracy of FNAC for salivary gland lesions were 93.48 %, 100% and 94.23 %, respectively. Conclusion: Fine-needle aspiration cytology is a very useful diagnostic tool for superficial palpable tumors of salivary glands. It has high rates of sensitivity, specificity, positive predictive value in diagnosing salivary gland lesions and hence a valuable tool in the diagnosis and management of patients.