Background: Pathology is considered by 2nd-year MBBS medical students to be an interesting and useful but most difficult subject. The problems of memorizing and volatility of the subject faced by the students can be tackled by making them learn by putting them in a particular situation and giving them a task as a source of learning, comparable to an actual task that he may face in his future professional life, addressed to as “Problem-based learning” (PBL). Methods: The Cross-sectional study was carried in Narayana medical college, Nellore. The participants were 150 2nd MBBS students (regular batch) who have completed 3rd semesters of pathology. Data were collected at the end of 3 semesters of pathology using a predesigned questionnaire. Data entry and analysis was done using Microsoft Excel. Percentages were used to analyze the data. Results: A total of 150 students (regular batch) who were going to appear for the 2nd MBBS university exams participated in our study. All of them returned the completed questionnaire. Of the 150, 88% were female students, and 12% were male students. A vast majority of the students, 98 %, found pathology to be an interesting subject. The majority of the students, 80%were satisfied with the content of the lectures taken and only 12.5%, felt otherwise. Blackboard teaching (87%). Conclusion: The study showed that most students had a positive attitude towards pathology. Students are in favor of the use of blackboard teaching, PowerPoint presentations, case-based discussions and integrated teaching.