The purpose of this investigation was to carry out an exhaustive review of the relevant previous research in order to ascertain the underlying causes of the observed discoloration and determine which component, if any, was to blame. A number of phrases taken from previously conducted systematic reviews were used in the search conducted in PubMed. There were a total of 389 teeth treated across eleven different trials that were discovered. Although it was seen more often with the use of the triple antibiotic paste that included minocycline, discoloration was shown to be substantially associated with the utilisation of other components as well. It is strongly suggested that you reevaluate your decision to use minocycline as the intracanal drug in conjunction with the other two antibiotics in the paste. The use of calcium hydroxide or an antibiotic paste containing both metronidazole and ciprofloxacin could be necessary in order to achieve the desired level of discoloration control. The presence of mineral trioxide aggregate was also associated with the discoloration. On the other hand, there is little evidence to suggest that any other material could possibly function as an acceptable coronal barrier. Because discoloration is a result that has a direct impact on patients, further research is required to determine the underlying causes of discoloration.