Gall bladder disease is rather encountered on a daily basis in the OPD’s now a day[1]. Many of these get admitted. Most of the cases admitted in the hospitals require radiological intervention. Routine examination of the gall bladder using USG is difficult and challenging. After cholecystectomy has been done it shows different histopathological changes ranging from inflammation to premalignant and carcinoma. This study puts in an effort to find the answer for the same.