Introduction: The most common malignancy encountered, in current setup is breast cancer in females. It stands second, as the most common cause, of death caused by cancers in developed countries. The diagnosis of the variants of breast cancer can be done with aid of immunohistochemistry (IHC) that is expression of ER, PR, Her2/Neu, and this has led to application of multiple systemic therapeutic strategies. The purpose of this study is to find the proportion of triple negative breast cancers in the study group and to compare the clinical features, natural history and outcome of Triple Negative Breast Cancer (TNBC) to other non-triple variants of breast cancers. Materials and methods: Analysis of retrospective clinical database was performed for 100 cases for the duration of 3 years (2017-2019). Clinical, histopathological and IHC patterns were compared under various headings. Results: Significant difference was found between the two groups in the variables such as age of diagnosis, tumor size, grade, lymphatic spread and prognosis. The patterns of reference amongst them show qualitative difference with triple negative group in view of risk of recurrence which peaked at 4 years and declined rapidly. On the contrary the others presented with constant risk of recurrence over a period of time. Conclusion: Triple Negative Breast Cancer has a more aggressive clinical setup as compared to others, although the findings are transient. The morphological characteristics alone cannot be used to classify breast cancers in two subtypes with different prognosis.