Hypodontia is a congenital absence of one or more teeth. It is a common malformation with a variable etiology. Early diagnosis and multidisciplinary intervention is required to reach an optimal outcome. Orthodontic treatment is often required to manage space and facilitate later restorative treatment. This article describes a multidisciplinary treatment approach for congenitally missing maxillary lateral incisor and second premolars involving orthodontics and prosthodontics specialties.