Diabetes mellitus has over the years become a public health issue. It is a complex disease which is characterized by chronic hyperglycemia. The present study was designed to determine some platelet indices in Type 2 Diabetic Mellitus (T2DM) patients compared to non-diabetic controls. A total of 240 subjects comprising 120 T2DM (60 males and 60 females) aged 20-55 years and 120 apparently healthy age and gender-matched controls were recruited for the study. Blood samples (5.0ml) were collected from each subject for the analysis of the parameters using Mindray 530 BC automated analyzer, Mindray, Japan. The data was analyzed using T-test and level of significance set at p < 0.05. The result revealed significant increase in the platelet indices involving the Mean Platelet Volume (MPV) (12.17 + 0.78 vs 7.80 + 1.18), Platelet Distribution Width (PDW) (14.41 + 1.5 vs 9.30 + 0.92) and plateleterit (PCT) (0.27 + 0.32 vs 0.17 + 0.00) between the T2DM patients and non-diabetic controls. This finding supports platelet activation in T2DM patients.