Sepsis is a major health problem, that significantly increases the mortality and morbidity of patients. The prognostic value of Platelet indices in septic shock has not been established. Our study aims to know the importance of platelet indices in sepsis and their value in prognosis. Details of sepsis patients from September 2018 to August 2019 were taken from case sheets and Hospital Information Management System (HIMS) in GEMS medical college and hospital, Srikakulam. Platelet (PLT) indices were recorded on the day of admission and the fifth day in hospital. The data were compared between revived and succumbed patients. A total of 100 septic shock patients were studied, of them, 55 were revived and 45 succumbed. Mean Platelet Volume (MPV) in the succumbed group was significantly higher than that of the revived group. Platelet Distribution Width (PDW) and Platelet Large Cell Ratio (PLCR) were increased, while Plateletcrit (PCT) and PLT count decreased in the succumbed group. A statistically significant difference was seen between revived and succumbed patients for PLT count and MPV which make them useful prognostic markers for patients in septic shock.