Background: Nursing is known to be stressful. Stress detrimentally can influence job satisfaction, psychological well-being, and physical health. There is a need for increased understanding of the stress that nurses experience and how best to manage it. The best coping predictors of mental health were escape–avoidance, distancing, and self-control. Other significant predictors of mental health were support in the workplace, the number of years worked in the unit, and workload. Method: Quantitative cross-sectional study design was used to determine the stress level and coping strategies at tertiary care hospital. 120 nurses working at gastro, medical and surgical wards were selected as sample. Data was collected through the standardized well adopted 31 item questionnaires. Results: results revealed that only (62) 57% nurses are suffering from stress and the used different strategies to manage the stress such as Prayers 55%, Sleeping 9%, exercise 2%, Spending times with friends 5%, Silence during problem 2%, Plan for tour 8%, Music therapy 10%, Walking 1%, Painting 3%, Set prioritises to avoid stress7%. Conclusions: Thus, the process of identifying nurses’ coping with job stress which is linked with the deep and authentic experiences of nurses in relation to job stress, the hidden and visible factors, strategies and methods of nurses’ coping, and also the factors and conditions affecting the coping process of nurses, provide backgrounds and necessary knowledge in order to adopt strategies that reduce or control occupational stress and stressors.