Research conducted to identify the etiologic features of Class III malocclusion showed that this type of deformity involves not only jaws, but the total cranio-facial complex, making it a difficult anomaly to understand. Majority of patients presenting with Class III malocclusions have a combined skeletal and dental discrepancy, making the factors contributing to this anomaly, complex. In skeletal Class III cases, it is challenging to obtain an esthetically and functionally sound occlusal outcome, only with orthodontic treatment. Furthermore, owing to its high rate of relapse it is difficult to maintain a constant post treatment occlusion. The clinical success of orthodontic mini-screws is dependent on many factors such its material characteristics, biomechanics, surgical technique, clinician’s experience, bone depth and quality, primary stability of the mini-screw and oral hygiene of the patient. However, despite its large-scale application in routine orthodontics, its success rate can be further improved. The present article demonstrates the effect of mini-screws on skeletal class III treatment.