Introduction: Follicular hyperplasia of the gall bladder is an extremely rare and benign entity characterized by hyperplastic lymphoid follicle with germinal center consisting of the lymphoid population. The lymphoid hyperplasia of the gallbladder is a rare condition, which can be diagnosed only by performing a histological examination. Here, we present the case of a 36-year-old woman with complaints of repeatable pain in the area of the right hypochondrium for a few months. Ultrasonography revealed chronic cholecystitis with a concrement in the lumen. Methods and Materials: We were reported a rare case of follicular hyperplasia of gall bladder in a 36 yrs old female presented into the department of surgery with a right side upper abdomen pain then she was diagnosed as cholecystitis and managed by cholecystectomy and specimen was received and processed for histopathological examination. Results: Due to chronic cholecystitis patient present with right upper abdominal pain and upon histopathological examination diagnosed incidently as follicular cholecystitis. Conclusion: Histopathological examination reveals a rare case of follicular cholecystitis A cholecystectomy was then performed. Histology shows nests of cells with lymphoid origin in the lamina propria, a multitude of lymphoid follicles and areas with pyloric metaplasia in the gallbladder wall. The case presented herein is of reactive lymphoid hyperplasia resembling a lymphoma combined with chronic cholecystitis, pyloric metaplasia, and cholelithiasis.