Aim: Rapid fixation -Is it an an effective method in the diagnosis of cytological smears. Objective: 1) Is it an accurate method in fine needle aspiration cytology. 2) Is it an accurate method in the diagnosis of various body fluid cytology. 3) To analyse the quality of background staining and cyto-morphology. 4) To compare the quality between rapid and routine fixation method. Methods: Smears are fixing in 95% isopropyl alcohol and stained by hematoxyline and eosin and papaniecolou staining. Result: The cyto-morphology and background staining quality in rapid fixation and routine fixation were analysed and are almost equal to routine fixation method. Conclusion: By rapid fixation the adequacy of the smears can be screened and analysed quickly. So we can reduce the turnaround time (TAT) and more benefit for the patient