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Saudi Journal of Pathology and Microbiology (SJPM)
Volume-4 | Issue-11 | 779-786
Original Research Article
Analysis of Tumor Vascularization By- Microvessel Density and Cd 34 by Immunohistochemistry- It’s Prognostic Significance in Differentiating Benign and Malignant Ovarian Surface Epithelial Tumors
Shyamala Srujana, SSS Quadri, N. Srimani
Published : Nov. 6, 2019
DOI : 10.36348/sjpm.2019.v04i11.001
Abstract
Ovarian neoplasms have become increasingly important not only because of the large variety of neoplastic entities but more so because they have gradually increased mortality due to female genital cancers. Ovarian carcinoma represents the sixth most common female cancers and the fourth leading cause of death due to cancers in women. Surface epithelial tumors were commonest variety of ovarian tumors followed by germ cell tumors. Angiogenesis is a critical factor in tumor growth and metastasis, because tumor proliferation is severely limited by nutrient supply to proliferating tumor cells. Hence tumorigenesis of malignant neoplasms associated with extensive neovascularization. The analysis of tumor vascularization by microvessel density (MVD) and it’s prognostic significance has been evaluated in many tumors including ovary. Many studies have established MVD as an important prognostic factor in solid tumors, but there is paucity of literature regarding characteristics of the tumor blood vessels in ovarian surface epithelial tumors. The present study aims to evaluate not just the density of microvessels in ovarian surface epithelial tumors but also the maturity characteristics of proliferating tumor blood vessels with the aid of IMMUNOHISTOCHEMISTRY there by differentiating between benign and malignant epithelial tumors of ovary and predicting the prognosis. Objectives: 1) To determine the incidence of ovarian surface epithelial tumors at our hospital. 2) To clarify the differences in angiogenesis between benign and malignant epithelial tumors.
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