Background: Squamous cell carcinoma is most common malignancy of the oral cavity occurring in 5th and 8th decades of life. Histopathological grading of the tumour is important to assess the biological behaviour of the tumour which has prognostic significance. Aim: To evaluate the prognostic significance of Broder’s and Bryne’s grading system in oral squamous cell carcinoma by comparing with histopathological prognostic factors. Materials and methods: This is a retrospective study of 45 cases of oral squamous cell carcinoma received from department of General surgery and ENT during January 2016 to June 2019. Broders and Bryne’s grading systems were compared with different prognostic factors like tumour budding, worst pattern of invasion and mitotic activity. Results: Review of 45 cases of oral squamous cell carcinoma showed tongue to be common site (51.11%).Common age of occurrence was 50-70 years with male predominance (66.67%) on analysing worst pattern of invasion in both grading system Bryne’s grading showed correlation with WPOI (P value-0.00001) and tumour bud/low power field (P value 0.001). Broders grading didn’t show prognostic significance when compared to Bryne’s grading. Conclusion: TNM staging system cannot assess aggressive clinical behaviour of oral squamous cell carcinoma. Broders histopathological grading system did not have prognostic significance when compared to Brynes invasive front grading system which is multifactorial grading.