Background and objectives: Carcinoma prostate is becoming an increasingly significant international health problem. Perineural tumour growth is associated with adverse prognostic features and a poor outcome; hence is a necessary component in histopathological reporting of malignancy. For accurate detection of perineural cancer spread, immunohistochemistry (IHC) with S100 was performed along with haematoxylin and eosin (H&E) stain. This study attempts to correlate the clinic-pathological prognostic factors with PNI, in a regional scenario. Methods: A retrospective study was conducted at a tertiary care hospital over a period of one year. Specimens were trurcut biopsy, TURP chips and prostatectomy specimen, sent in 10% formalin. Paraffin embedded blocks was stained with H&E and representative sections with S100. Relationship of tumor with nerve was established and graded accordingly as: Category 0: nerves without immediate tumor-cell-contact. All nerves being fully surrounded by tumor (classical perineural invasion) were categorized group 3. Two further categories discriminated between nerves that were touched either by carcinoma cells below 50% of the circumference (category 1) or above 50% as category 2. Results: Out of 30 cases of prostatic adenocarcinoma, majority of specimens were needle biopsies (47%). The age of presentation were 55-84years with mean age being 68.93 years. Pretreatment and posttreatment PSA levels were assessed. Most common presentation was bladder outlet obstruction (57%) and treatment given was radical Prostatectomy (44%). Perineural invasion (PNI) was seen in 66.7% of cases and correlated positively with Gleason’s score, pT categories, %PSA. Perineural spread noted in 73.3% cases and negatively correlated with Grade group.