Background: Patients need enough food to recover from any disease. Patients with serious illnesses have high nutritional requirements and can become malnourished very quickly. Research findings suggest that early nutrition is important for patient outcomes. The nutritional needs of all patients are reviewed daily and nutrition is initiated as soon as possible, usually on the first day of admission. In critical care areas, enteral feeding is used to overcome malnutrition conditions and to keep patient in the safety side. Therefore, enteral nutrition is considered an easier method and cheaper when compared to parenteral nutrition which has more complications and costlier, additionally, having enough knowledge about enteral nutrition by the nurses is considered very crucial to administer the enteral feeding to patients in the proper way at the critical care units. Method: Non-experimental, cross-sectional research design which will identify nurses’ knowledge regarding enteral feeding among cardiac nurses at CCH. The study will describe knowledge by using a quantitative method. The research will be conducted in Cardiac Center Hail, Ha’il Region, Kingdom of Saudi Arabia, and will focus on all cardiac nursing care units. Results: The data obtained from this study were analyzed using the Statistical Package for Social Science (SPSS) 25.0 program. A descriptive statistical analysis using means, frequencies, percentages, and standard deviations was used to describe the demographic variables and answer question 1. Kruskal-Wallis was used to determine if there are significant differences among the means of the groups (more two groups) and Mann-Whitney (independent-samples) for questions 2, because the data doesn’t follow normality distribution, where of the Table 2, we find that the significance level of the Kolmogorov-Smirnov test was less than 0.05. This leads us to reject the null hypothesis that the data follow the normal distribution, so we used nonparametric tests. Conclusion: The nurses’ knowledge regarding enteral nutrition at the cardiac nursing units were enough under safe practices. The in-short activities of Continuing Nursing Education had a positive effect in improving the nurses’ knowledge and practices regarding enteral nutrition in the in-patients’ departments at Cardiac Center Hail.