The study explored perceived challenges faced by student-teachers during the off-campus teaching practice. A descriptive survey design was adopted for the study. The population for the study was all the student-teachers (300, 350, and 400 levels) from College of Education (Regular), University (Regular), University (Sandwich), and other modes of education. However, 135 student-teachers were randomly and conveniently sampled for data collection. The instrument used for the study was an adapted questionnaire. The instrument was validated from an expert perspective. Data to answer research questions were analysed using the means and standard deviations. The study found that student-teachers do not have personal challenges during their teaching practices. The study found that student-teachers do not have supervisory challenges during their teaching practices. The study also revealed that student-teachers do not face major challenges from their practicing schools during their teaching practices. It is recommended that Colleges of Education, Teacher Continuous Professional Development of the Universities, as well as Ghana Education Service should organise periodic workshops for student-teachers and in-service teachers on the selection of appropriate TLMs for various lessons.