Saudi Journal of Pathology and Microbiology (SJPM)
Volume-4 | Issue-08 | 614-617
Case Report
Histiocytic Sarcoma: A Very Rare Tumor in a 97 Year Old-A Case Report
Amal Ali Hassan, Mohammad Shahid Iqbal, Aisha Tabassum, Muhammad Sayeed
Published : Aug. 28, 2019
Abstract
Histiocytic Sarcoma (HS) is an extremely rare tumor with aggressive course and arises in lymph nodes and extra nodal
sites. We present a case of HS in a 97-year-old male patient with non-specific clinical features. CT scan revealed left
axillary lymph node enlargement and a hypo dense lesion in spleen. On Lymph node biopsy, a diagnosis of HS was made
based on the histomorphology and immunopositivity of tumor cells for CD68 and CD 163. Negative markers ruled out
the other mimics. Considering his age of 97 years, he was not considered to be suitable for surgery or aggressive therapy.
HS is an extremely rare neoplasm and it is a diagnosis of exclusion. The key to diagnosis is immunohistochemistry.
Molecular genetic studies have reported a few abnormalities and needs to be confirmed.There is no standard protocol for
the management of HS due to its rarity.