Oral submucous fibrosis (OSF) is an insidious, chronic, progressive, debilitating disease. It has amalignant potential resulting from progressive juxtaepithelial fibrosis of the oral soft tissues, resulting in increasing loss of tissue mobility, marked rigidity and an eventual inability to open the mouth. The hallmark of the disease being sub mucosal fibrosis that affects most parts of the oral cavity, pharynx and upper third of the oesophagus and its clinical presentation depends on the stage of the disease at detection. As the disease has a spectrum of presentation, the management differs with the various stages of the disease. This articles presents a review of the existing literature pertaining to the effectiveness of medical management of Oral submucous fibrosis in its initial stages