Saudi Journal of Medicine (SJM)
Volume-4 | Issue-03 | 180-185
Original Research Article
Study of Serum Lipid Profile in Patients of Alcoholic Cirrhosis
Hardip Singh, Sapinder Pal Singh, K. K. Oberoi, Gurparampreet Kaur Sidhu, Danish Sood, Sukhminder Singh, Ajay Jolly, Gaurav Omprakash Dubey
Published : March 30, 2019
Abstract
Introduction: Alcoholic cirrhosis is the end spectrum of alcoholic liver disease (ALD), which includes fatty liver or simple steatosis, alcoholic hepatitis, fibrosis, cirrhosis and super-imposed hepatocellular carcinoma. Although several studies have been conducted on dyslipidemia in cirrhotics in developed countries, there is a paucity of data in this regard in India. As there is a high prevalence of chronic liver disease in our country, we conducted this study to determine lipid levels in patients with cirrhosis and to assess if it relates to the severity of cirrhosis according to pughcriteria. Materials and methods: This is a cross sectional case-control study conducted on alcoholic cirrhotic patients and 50 healthy individuals (controls) without history of alcohol consumption. All the cases were investigated for fasting lipid profile and ultrasonographic evidence of cirrhosis. Biochemical tests including liver function tests were performed, which assisted in the diagnosis of alcoholic cirrhosis. These include serum bilirubin, total serum protein, serum albumin, serum globulin, aspartateaminotranferase (AST), alanineaminotransferase (ALT) and alkaline phosphatase (ALP). The data was collected systematically and analysed statistically according to the standard statistical methods. Results: Serum total, LDL, HDL, VLDL, cholesterol and trigylceride level in patients with cirrhosis is inversely correlate with severity of cirrhosis