Background: Blood transfusion services play a vital role in the modern healthcare scenario, and blood and its components requirements widely outstrip the supplies therefore a stringent guidelines for transfusion, blood donations and utilization should be laid down and adhered. This study analyses the causes for discard of blood and its components. Materials and Methods: This was a retrospective study of various causes of discard of blood and blood components carried out in blood bank unit of a tertiary care hospital from the data collected from the blood donations by the voluntary donors from January 2014 to May 2017. Results: A total of 3442 blood bags were collected of which 3378 (98.14%) were from male donors and 64 (1.85%) were female donors. majority of the donors were in the age group of 21-30 years (55.37%). a total of 5453 blood /blood components were prepared of which 393 units of blood /blood components were discarded with an overall discard rate of 7.22%. discard rate for WB, PRC, FFP and platelets were 9.22%,4.12%,7.9% and 28% respectively. Conclusion: To prevent wastage of blood a proper coordination should be present between the clinicians and blood bank personnel. An updated software and automation, proper training of staff and a properly implemented blood transfusion policies would go a long way in reducing wastage of this vital body resource