The study examined the role of work-family conflict on two groups of mothers whose ages were between 25 years and 42 years with a mean age of 34.5 years. Both groups of mothers were involved in paid and self-employments in a University sub-urban town, South-South Geo-Political Zone of Nigeria. A survey research design was utilized in which a survey questionnaire was used in selecting 102 mothers. Out of this number, 62 (63. 24%) of these mothers were in self employments, whilst 40 (40. 8%) of them were in paid employments. One research question / research hypothesis was formulated which guided this study and one research instrument namely, work-family conflict a 12-item questionnaire was used as the research instrument [1] with a reliability index of 0.82. The simple mean (x), standard deviation (sd) and a t-test were computed for the two groups of mothers. The independent t-test statistic computed revealed the manifestation of work-family conflict in both groups of respondents (P > 0.05; T = 1.04; DF = 100; SD = 3.805, Mean = 12.895). In order to mitigate the stressful effects of work-family conflict on mothers whether in paid or self-employments, spousal, emotional support and good time management were recommended. The study concluded by asserting that both mothers in paid and self-employments manifested evidence of work-family conflict