This study investigates the link between organisational ergonomics and academic staff performance in federal universities in the South-South zone of Nigeria. It sought to examine the extent of the influences of three organisational ergonomic dimensions (teamwork, job design and effective communication) on the research output- a proxy for academic staff performance. A total of 7,086 academic staff constituted the population of the study. Primary data were collected from a sample of 1,236 respondents that were drawn from the population using the questionnaire. Data obtained were analysed using descriptive statistics, Pearson product moment correlation and multiple linear regression techniques. Results revealed that teamwork had the highest significant level of influence on the research output. This was followed by job design and effective communication. It was therefore concluded that organisational ergonomics has a significant positive influence on the research output of academic staff. Hence, management of Nigerian universities should prioritise the practice of organisational ergonomics and also pay attention to the implementation of policies that would encourage research collaboration among academic staff in their institutions