The need for Nigerian organizations to pay attention to cross-cultural management practices have become necessary following the challenges posed by cultural diversity and tribal sentiment in many states of the country. These barriers add to the usual challenges that entrepreneurs face with regard to capacity, financing, and market access. This study accesses Cross Cultural Management and Entrepreneurial Environment in Nigeria using intercultural communication and entrepreneurial mobility as proxies of study. The specific objectives of the study are to determine the factors affecting cross cultural management in Nigeria and to ascertain the behavioral aspect of managers in managing cross cultural business in Nigeria. The study revealed that the understanding of some basic cultural differences can help foster the movement of various entrepreneurial resources from one place to another without any form of barrier and cultural shock. The study concludes that Cross cultural management expands the mobility of pool of potential entrepreneurs, builds incentives for entrepreneurship, eases the costs of doing business, helps industrialize local communities and generates healthy competition. The study recommends that policymakers should create proactive cross-cultural communication education and entrepreneurs should understand cultural sensitivities, avoid conflict and appreciate how words, tonality, and body language vary with every culture