This review's objective is to provide you with the most recent data about POEMS syndrome. The authors reviewed, compared, and assessed key findings after conducting a literature search of the accessible sources explaining POEMS syndrome. According to the results of this study, POEMS syndrome is related to a class of diseases called monoclonal gammopathies or plasma cell dyscrasias. The unchecked growth of a single clone (monoclonal) of plasma cells causes an abnormal buildup of M-proteins (also known as immunoglobulin) in the blood, which has a detrimental effect on the quality of life for both the patients and their family. To minimize or even eliminate the symptoms, early and appropriate diagnosis and therapy/Treatment are necessary.