The existence of human resources in an organization is a valuable asset for the organization itself. Civil Servants (PNS) or now called the State Civil Apparatus (ASN) as human resources in government become the backbone of the government in running the government. In accordance with Law No. 39 of 2008 concerning the State Ministry, it is stated that the Ministry of Foreign Affairs is one of 3 (three) ministries that cannot be dissolved by the President. Thus the position of the Ministry of Foreign Affairs has a significant role in the government. So with these conditions, it is important for the Ministry of Foreign Affairs to have human resources who are committed to remembering their actions not only in the country but giving Indonesia's image to the international world. The objectives of this study are to find out and explain the effect of career development (x1) and compensation (x2), on job satisfaction (y1) to organizational commitment (y2) in the Ministry of Foreign Affairs. The sample of this research is the employee of general secretariat of foreign ministry by employing descriptive statistics and data analysis technique using SmartPLS version 3.2.7 as the research methodology. The research reveals that career development, compensation, and job satisfaction have positive effect to the organizational commitment, both partially and simultaneously. Partially, only career development has insignificant effect to the job satisfaction, while the remaining variables have significant effect.