Choriocarcinoma is a malignant proliferation of the trophoblastic epithelium, not including chorionic villi but permanent vascular invasion. It is a rare tumor, most often of gestational origin, occurring in 75% of cases after a molar pregnancy. Choriocarcinoma in postmenopausal period is very rare however some cases of choriocarcinoma developing after a long latency period from the last pregnancy have been reported. We report an original case of a postmenopausal woman with non-gestational endometrial choriocarcinoma occurring 14 years after menopause. There are no well-defined guidelines for the treatment of postmenopausal choriocarcinomas. Their prognosis is very unfortunate, yet it has changed completely, from 19% to 90% survival since the onset of chemotherapy