Introduction: Breast cancer is the furthermost typically identified life-threatening most cancers in female and the foremost motive of most cancers loss of life among women. Aims and Objectives: Due to the absence of information involving breast cancer in Jouf region, KSA. Our study was directed to discover out the level of their knowledge about breast cancer and practice of breast self-examination amid the study population. Material and Methods: Descriptive study including 755 Saudi volunteers living in Al- Qurrayat, Northern Saudi Arabia. Only for women agreeing to take part in the breast self-examination workshop had been blanketed and completed items of a scale assessing the knowledge level, attitudes regarding breast self-examination. Results: A total of 618/755 (81.9%) participant (622 females and 133 males), successfully completed the data. the majority of the participant about 34.7% were between 26-35 year. the level of knowledge in the participants about breast cancer perception according to their education is 16.6% of the respondents had no knowledge, about 5.7% of them complete the university. Also, 65.4% of the respondents had little and moderate knowledge and only about 17.4% had a good knowledge of breast cancer. In addition, 14.4% of female and 0.3 % of the male population had no knowledge about breast self-examination. Furthermore, 345 out of 755(45.7%) study population interested to get information about breast cancer were university educated. Conclusion: breast self-examination necessities to be taught to all women, irrespective of their education level