Klebsiella pneumoniae, Gram Negative, capsulated rod shaped Bacilli is responsible for causing life threatening infections in humans and also opportunistic bacterial pathogen of clinical relevance for its association with both nosocomial infections and community acquired infections.Moreover, increased resistance to these antibiotics complicates and limits the available therapeutic drug options for the clinicians. Hence this study was taken to investigate the antimicrobial drug resistance and Prevalence of ESBL producing Klebsiella pneumoniae. This is a Retrospective study conducted at from JANUARY 2018 to DECEMBER 2018 at Saveetha Medical College and Hospital included Sputum sample of 3125 in patients from various Department, out of which 2154 had growth, from which 1320 Klebsiella pneumoniae isolates were collected. Patient’s demographic details, co-morbid conditions other associated risk factors were also collected. Antibiotic susceptibility testing (AST) was done on Muller Hinton agar by Kirby bauer method as described by the Clinical Laboratory Standard Institute (CLSI). The result shows 1320 Isolates, resistance to antibiotics like (Amoxicillin intrinsically resistance), Cefepime (70.8%),Ceftriaxone (67.5%), Cefuroxime (58.3%), Gentamycin (43.3%) and 726 ESBL producers (55%) which clearly point towards the multi-drug resistance of Klebsiella pneumoniae isolates and ESBL producers were significantly more resistant compared to ESBL nonproducers. Hence, Routine ESBL testing should be done along with antibiogram for the proper treatment of patients and also to prevent the development of multi drug resistance.