Background: Rickettsial infections are attributed as one of the important cause of pyrexia of unknown origin and there is a need to be differentiated from other common febrile illness. This study was conducted to know the prevalence of rickettsial disease among febrile patients since scrub typhus is endemic in our district in monsoon season the prevalence of scrub typhus is also studied. Materials & Methods: Clinical data and history collected from all PUO patients. A careful search of eschar was performed in all patients, peripheral smear, rapid test for Malaria, widal, Dengue NS1 done accordingly based on the clinical data. Serum samples collected from all the cases and weil felix test was done. Most of the samples were reactive to OX-K antigen, they were subjected to scrub typhus investigation. IgM ELISA was done for scrub typhus. Results: Out of 180 patients 58 (32.22%) were positive for weil felix test. Among the 58 positives 28 (48.27%) were positive for OXK antigen suggestive of scrub typhus. Out of 28 patients 27 (96.45%) were positive in both ELISA & ICT. Only 1 (3.57%) was negative by ICT but positive in ELISA. Seropositivity of scrub typhus is higher in Males in the age group 30 – 45yrs .Fever with chills was present in all cases & headache followed by rashes was the next common finding in all patients with scrub typhus. Conclusion: In our study the Seroprevalence of scrub typhus throws a light that, this has to be included in the fever panel in differential diagnosis, which will help in timely diagnosis and adequate treatment can be given and avoid complications.