In order to know the prevalence of rubella among pregnant women and, if possible, to introduce the rubella test in the antenatal check-up to improve the follow-up of pregnant women, we studied the seroprevalence of rubella among women pregnant who came to antenatal care in the third health district of the city of Lome. The objective of this study was to study the immune status of pregnant women against rubella and, more specifically, to assess their level of knowledge about this viral disease, which is considered infrequent in developing countries. We conducted a prospective cross-sectional study that allowed us to randomize 150 pregnant women. The data was analyzed with the Epi-Info version 6 software. With 150 women who participated in the survey, the results showed us a prevalence rate as follows: immunoglobulin G +, immunoglobulin M- (66.7%); Immunoglobulin G-, Immunoglobulin M- (25, 3%) with a suspicious population of 8%. In knowledge of the disease, only 26% of pregnant women had knowledge of the disease. None of the 150 women have been vaccinated against rubella. In view of the possible congenital consequences of rubella, the authors recommend systematic screening of pregnant women for prenatal consultation