Currently, both job stress and presenteeism are critical problems. Job stress carries enormous costs for healthcare workers and nurses in terms of overall wellbeing, presenteeism, and turnover, which in turn affect the quality of patient healthcare services. The objectives of this research were to uncover the extent of presenteeism and job stress among nurses in hospitals in Hafr Al-Batin, a city in the Kingdom of Saudi Arabia. A descriptive, correlational, cross-sectional study was conducted. The study sample included 146 nurses working in Hafr Al-Batin hospitals. Data were collected from May to June 2020. For analysis, the researcher used two tools, the Expanded Nursing Stress Scale (ENSS) and the Stanford Presenteeism Scale-6 (SPS-6). The data was subsequently analyzed by descriptive statistics and Spearman’s correlation coefficient. Study results showed that the mean values of job stress and presenteeism were both high. Furthermore, there was a relationship between the overall presenteeism and overall job stress experienced among staff nurses. The results of this research would aid both nursing administrators and hospital managers in designing effective strategies to reduce job stress and manage presenteeism among staff nurses in the hospitals of Hafr Al-Batin.