Propranolol is β-adrenergic receptor blocker with reported antioxidant effect and anti-inflammatory action , is used in treatment of hypertension mainly, and the main benefit in treatment patients with angina pectoris or myocardial infarction, add to role in central nervous system diseases as migraines and anxiety disorders, and tremor but rarely used in gynecology field in spite of many action either by beta receptor block or other mechanisms it acts with, such as anti _inflammatory, anticancer, antioxidant activity, pro_poptosis, and wound healing. In this review, we have discussed the various aspects of propranolol that can be applied in clinical gynecology in number of ways such as local contraceptive, in the treatment of Vulovaginitis by affected main criteria of Trichomonas and Guardia lamblia ,which is motility ,propranolol inhibited motility of both organism and consequence inhibition of the growth of both organism, for the treatment of genital hemangioma, We have also shed some light on experimental studies _ such as its effect on polycystic ovary and endometriosis