Background: Dermatological lesions display a wide spectrum of diseases. Although common in the developing countries, they are not considered significant on assumptions of being always non-lethal and insignificant but are sometimes indicators to underlying systemic diseases. Aims and objectives: To observe and analyse the spectrum of dermatological disorders through histopathological examination. Material and Methods: This was a prospective study, carried out at tertiary care centre of Ahmedabad, Gujarat, India. A total of 127 cases including punch and excision biopsies of skin were studied over a period of 1 year and 6 months. Results: Out of the total 127 cases, 56 were males and 71 were females showing a slight female predilection. Skin lesions were divided into six groups of which inflammatory, malignant & benign neoplastic; & infectious skin lesions showed female predilection while spongiotic, psoriasiform and lichenoid skin lesions as well as leprosy and tuberculous skin lesions showed male predilection. Vesicobullous lesions were found to be gender neutral. The overall male to female ratio was found to be 0.8:1. Inflammatory lesions (33%) of skin formed the most common group of skin lesions in this study followed by benign tumours/cysts (27.5%) of skin. Conclusion: Skin lesions show a wide variety of histomorphology and they are sometimes an important manifestation of systemic diseases. Hence, a proper histopathological examination remains the gold standard in diagnosing skin diseases.