In this short communication, an integrated process concept for detoxification of chromium (VI) contaminated water with Polyaniline/MCC composite is proposed. The preparation of composite involved in-situ oxidative polymerization of aniline in the presence of MCC (a bio-based material); the industrially favorable and cost effective oxidant ammonium persulphate (APS) was used. Under the conditions studied, the preliminary results reflected that the proposed concept was quite effective in the detoxification of the model solution. It is worth expecting that the use of PANI-engineered cellulose fibers prepared using low cost oxidant may serve as an interesting alternative for industrial water treatment.