Hypertension (HTN) is an asymptomatic easily detectable chronic cardiovascular disorder which can cause coronary heart diseases, stroke and other complications. The relationship between trace elements and cardiovascular diseases is under investigation and showed conflicting results.In this study levels of magnesium, copper, zinc, iron in hypertensives were estimated and compared with normal healthy controls. A case control study was undertaken over a period of 6 months included 100 individuals aged between 25-65 years. 50 cases were hypertensive patients free from diabetes mellitus, thyroid disorders, any other chronic diseases, while 50 normal healthy subjects were controls. In both the groups, systolic and diastolic blood pressures, serum magnesium, copper, zinc and iron levels were obtained. The systolic and diastolic blood pressure, serum copper, zinc was significantly high (p value <0.05) and magnesium, iron levels were significantly low in hypertensives. Excess free radicals, increased stress has been implicated in the etio-pathogenesis of hypertension. Copper and iron increase the levels of free radicals acting as a pro-oxidant leading to increased peripheral vascular resistance and hypertension. Increased zinc can be due to intracellular increase in renal zinc favoring the activity of carbonic anhydrase and causing an effect opposite to that of some diuretics. Elevated zinc leads to high sympathetic nervous activity. Decreased magnesium potentiates vasoconstriction and increase vascular tone leading to hypertension. We conclude that there exists a relationship between serum magnesium, copper, zinc, iron and hypertension but, further large-scale population studies should be undertaken to establish the role of various trace elements in hypertension