Background & objectives: Polycystic ovary syndrome (PCOS) is the most common disorder of ovarian pathology in women of reproductive age group Insulin resistance and hyperinsulinemia may play an important role in pathophysiology of PCOS. To estimate fasting plasma glucose, plasma insulin levels, insulin resistance and lipid profile in obese and non obese female infertile women with PCOS. To study the association between insulin resistance, lipid profile and obesity in female infertility in PCOS. Methods: 30 obese infertile women diagnosed by ultrasonogram as PCOS and with a BMI> 30Kg/m2attending Gynecology OPD at Narayana medical college and hospital were taken as cases. 30 age matched non obese infertile women with a BMI<30Kg/ m2 were taken as controls. Results: In our study the fasting glucose, fasting plasma insulin values and insulin resistance was significantly elevated among cases when compared to controls (P value <0.001). The Mean ± S.D values of LDL cholesterol were elevated in cases when compared to controls (P value <0.001). Interpretation & conclusions: This clearly shows the importance of screening for dyslipidemia and insulin resistance in Indian Women with PCOS. Hence periodic monitoring of lipid profile and B.P specially for obese PCOS patients may be advised.