Prevention of diabetes and its associated burden has become a major health issue worldwide. The present study was undertaken to assess the changes in insulin sensitivity and endothelial dysfunction well before the onset of diabetes in population with positive family history for diabetes. The objectives of the study is to estimate the levels of serum Adiponectin, Visfatin, Insulin, HOMA IR and platelet derived microparticles P-selectin levels in offspring of type 2 Diabetes mellitus. The healthy volunteers who are aged between 18- 22 years of either sex, were selected based on their family history of diabetes. The study showed a significant decrease in serum Adiponectin and increase in serum Visfatin, Insulin, HOMA IR & P-selectin levels in the offspring of type 2diabetes. The Adiponectin showed a negative correlation with Visfatin, P selectin, Insulin & HOMA IR. Genetic predisposition for diabetes may influence adipocytokine levels which might play a key role in developing diabetes in near future.