Background: There is evidence that support the use of high sensitive C-reactive protein (hs-CRP) to monitor cardiovascular risk in diabetic and non diabetic individuals. This study aims to assess hs-CRP level in Sudanese with type 2 diabetes mellitus (D.M) and obese individuals; as a risk factor for cardiovascular diseases. Materials and methods: This cross-sectional study was conducted in Khartoum-Sudan from April to December 2018, 50 diagnosed Sudanese patients with diabetes mellitus attending Alarbaeen hospital in Khartoum state and 50 obese Sudanese individuals were enrolled in this study. Blood samples were analyzed for cholesterol and hs-CRP levels using Mindray BS-200 automated analyzer. Results: There were no significant differences in hs-CRP and total cholesterol levels in type 2 D.M when compared with obese. Both diabetic patients and obese had high levels of hs-CRP and total cholesterol. hs-CRP and total cholesterol levels revealed no significant difference when male compared with female in type 2 D.M as well as in obese. The majority of the study participants were found to have hs-CRP level more than 3 mg/L, which indicate a high risk to have cardiovascular diseases according to American Heart Association. There was no correlation between hs-CRP levels and total cholesterol levels in the study subjects. Age showed inverse significant correlation with hs-CRP levels in type 2 D.M and no correlation among obese. In conclusion: The higher levels of hs-CRP with higher levels of total cholesterol may be a predictive factor for developing of CVD in Sudanese with type 2 D.M as well as in obese.