Introduction: Always chronic kidney disease has been bound to diabetes mellitus, especially type2. Inflammatory biomarkers, such as CRP, IL6, cystatin C and TNF-alpha) are usually play role in the development and increase risk of type 2 diabetes T2DM, as well as chronic kidney disease, so this study aimed to evaluate renal function tests and inflammatory biomarkers among T2DM and compare evaluated parameters with data of healthy individuals. Methods: Two hundred (200) subjects were enrolled in this study, 100 of them were patients with T2DM set as case group, , age ranged 33 and 55 years, and the other 100 were healthy individuals were set as control group. Blood samples were collected from both groups in order to assess renal function tests urea, creatinine by means of spectrophotometer based method, while Sodium and Potassium by easylyte device instrument and inflammatory biomarkers CRP, IL6, cystatin C and TNF-alpha by ELISA technique. Results: Inflammatory biomarkers (IL-6, CRP, Cystatin C and TNF-alpha) levels in diabetic subjects were significantly higher than control group. We also found that serum creatinine and urea were higher in type 2 diabetes patients than normal subjects (p=0.001). Pearson’s correlation of serum creatinine and urea with inflammatory biomarkers brought different positive correlation with all parameters. Conclusion: Elevated levels of inflammatory biomarkers (IL-6, CRP, Cystatin C and TNF-alpha) are positively associated with renal function tests serum creatinine and urea and increased risk of type 2 diabetes.